Table of Contents
I Central nervous system diseases
1 Neuronal nicotinic acetylcholine receptor modulators : recent advances and therapeutic potential 3
2 Recent advances in selective serotonergic agents 17
3 BACE inhibitors for the treatment of Alzheimer's disease 35
4 Positron emission tomography agents for central nervous system drug development applications 49
II Cardiovascular and metabolic diseases
5 Emerging topics in atherosclerosis : HDL raising therapies 71
6 Small molecule anticoagulant/antithrombotic agents 85
7 CB1 cannabinoid receptor antagonists 103
8 Melanin-concentrating hormone as a therapeutic target 119
9 Glycogen synthase kinase-3 (GSK-3) : a kinase with exceptional therapeutic potential 135
10 Inhibitors of dipeptidyl peptidase 4 149
11 Recent advances in therapeutic approaches to type 2 diabetes 167
III Inflammatory, pulmonary, and gastrointestinal diseases
12 The TRPV1 vanilloid receptor : a target for therapeutic intervention 185
13 Leukotriene biosynthesis inhibitors 199
14 CXCR3 antagonists 215
15 PDE7 inhibitors : chemistry and potential therapeutic utilities 227
IV Cancer and infectious diseases
16 Inhibitors of anti-apoptotic proteins for cancer therapy 245
17 AKT kinase and Hsp90 inhibitors as novel anti-cancer therapeutics 263
18 Novel strategies in HIV prevention - development of topical microbicides 277
19 New developments in HIV therapeutics 291
20 Antibacterials for the treatment of gram positive infections 301
21 Progress on new therapeutics for fungal nail infections 323
V Topics in biology
22 Chemical tools for indications discovery 339
23 Structural genomics and drug discovery 349
VI Topics in drug design and discovery
24 G-protein coupled receptor inverse agonists : identification, pharmacological relevance and functional assays 373
25 The utility of metabonomics for drug safety assessment 387
26 Computational prediction of blood-brain barrier permeation 403
27 Pharmacogenetics and drug development 417
VII Trends and perspectives
28 Trends in pharmaceutical innovation 431
29 To market, to market - 2004 443
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