Cell表观遗传专刊

Cell表观遗传专刊

Cell关于表观遗传学的11篇文章

BeyondtheSequence:CellularOrganization
ofGenomeFunction
1,
*
Tom Misteli
1
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
*Correspondence: mistelit@mail.nih.gov
DOI 10.1016/j.cell.2007.01.028
Genomes are more than linear sequences. In vivo they exist as elaborate physical struc-
tures, and their functional properties are strongly determined by their cellular organization.
Idiscussherethefunctionalrelevanceofspatialandtemporalgenomeorganizationatthree
hierarchical levels: the organization of nuclear processes, the higher-order organization of
thechromatinfiber,andthespatialarrangementofgenomeswithinthecellnucleus.Recent
insightsintothecellbiologyofgenomeshaveoverturnedlong-helddogmasandhaveledto
new models for many essential cellular processes, including gene expression and genome
stability.

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