ȾɫÌåÉÏÓÐЩÌض¨µÄλÖñȽϴàÈõ£¬¿Æѧ¼ÒÃǽ«Ö®³ÆΪ´àÁѵ㣬ĿǰÒÑ·¢ÏÖȾɫÌåÉÏÖÁÉÙÓÐ75¸ö´àÈõµã£¬×îÖøÃûµÄÀý×ÓÊÇÒ»ÖÖ×î³£¼ûµÄÒÅ´«ÐÔÖÇÁ¦³Ù¶Û¼²²¡¡ª¡ªXȾɫÌåÒ×ÁÑÖ¢£¬ÕâÖÖ¼²²¡µÄ»¼ÕßÔÚXȾɫÌåµÄ´àÁѵãÉϺÜÈÝÒ׶ÏÁÑ£¬Ôì³ÉÒ»ÖÖÃûΪFMRPµÄµ°°×ÖʵĶªÊ§¡£
FMRPÓëÐÅÏ¢RNAÏ໥×÷Óá£È»¶ø£¬Ñо¿ÈËÔ±ÃDz¢²»Á˽âFMRPÓ°ÏìÐÅÏ¢RNAsºÍµ°°×Öʺϳɡ¢FMRPµÄȱʧµ¼ÖÂÖÇÁ¦³Ù¶ÛµÄϸ½Ú¡£ÔÚ4ÔÂÔÚÏß³ö°æµÄ¡¶×ÔÈ»¡ªÉñ¾¿Æѧ¡·ÉÏ£¬Ò»ÆªÂÛÎÄ̽ÌÖÁËXȾɫÌåÒ×ÁÑÖ¢µÄ²¡Àí»úÖÆ¡£
Claudia BagniºÍKirsten S. Dickson¼°Í¬ÊÂÃDZ¨¸æ˵£¬FMRPÎȶ¨Á˸ºÔð±àÂëPSD¡ª95µ°°×ÖʵÄÒ»ÖÖÐÅÏ¢RNA¡£PSD¡ª95¶ÔÉñ¾Í»´¥µÄ½á¹¹ºÍ¹¦ÄÜÖÁ¹ØÖØÒª¡£ËûÃÇÔÚȱʧFMRPµÄСÊó´óÄÔÖз¢ÏÖPSD¡ª95ÐÅÏ¢RNAÔÚ¿ìËÙÍË»¯£¬PSD¡ª95µ°°×ÖʵÄˮƽÔÚº£ÂíÇø¿ìËÙϽµ£¬º£ÂíÇøÊÇ´óÄÔÖиºÔðѧϰ¡¢¼ÇÒäºÍijÖÖÍÆÀíÄÜÁ¦µÄ¹Ø¼üÇøÓò¡£
й¤×÷°µÊ¾£¬ÐÅÏ¢RNAÔÚÉñ¾Ï¸°ûÍøÂç½»Á÷Öб£³ÖÎȶ¨µÄÖØÒªÐÔ¡£ËäÈ»»¹²»Äܽ«ËùÓеÄXȾɫÌåÒ×ÁÑÖ¢¶¼½âÊÍΪPSD¡ª95ÐÅÏ¢RNAµÄ²»Îȶ¨£¬µ«ÕâÖÁÉÙÊÇÕâÖÖ¼²²¡µÄÒ»ÖÖÖØÒªÖ²¡ÔÒò¡£
²¿·ÖÓ¢ÎÄÔÎÄ£º
A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability
Francesca Zalfa, Boris Eleuteri, Kirsten S Dickson, Valentina Mercaldo, Silvia De Rubeis, Alessandra di Penta, Elisabetta Tabolacci, Pietro Chiurazzi, Giovanni Neri, Seth G N Grant, Claudia Bagni
SUMMARY: Fragile X syndrome (FXS) results from the loss of the fragile X mental retardation protein (FMRP), an RNA-binding protein that regulates a variety of
Nature Neuroscience (08 Apr 2007) Article
ÉÏһƪ£ºNeuron£º¹ºÎïÊÇÖÖϲÔúÍÍ´¿àµÄÐÄÀí°ÎºÓ ÏÂһƪ£ºµ÷¿ØÉñ¾Ï¸°û¹Ø¼ü»ùÒòµÄ·¢ÏÖÓÐÖúÓÚËèÇʺϳÉÎÉÂÒµÄÑо¿
|
