研究者在4月1日的《血液》（Blood 2007;109:3080-3083.）杂志上报告，对急性成淋巴细胞性白血病(ALL)的成年患者，结缔组织生长因子(CTGF)在外周血或骨髓的表达似乎与结局相关。
美国Fred Hutchinson癌症研究中心的Sala-Torra博士及其同事一开始发现，CTGF是ALL患者B细胞最高度过表达的基因。它还显示异质性表达，提示它可能有预后相关性。为了进一步研究，研究者研究了79例ALL标本。CTGF表达水平在B系、细胞遗传学显示不利因素和表达CD34的原始细胞的情况下显著增加。
较高CTGF表达水平与总生存较差相应。特别是，5年生存在最低CTGF表达组为58%，中等CTGF表达组为42%，最高CTGF 表达组为11%。这使得CTGF表达每增加10倍，总生存变差的危害比为1.36。
研究者指出，进一步的研究正在进行，以证实CTGF表达对ALL的预测价值，并研究其在正常和异常淋巴细胞生物学中的作用。假若CTGF在恶性转化中起作用，那么它可能也是一种治疗靶标。
原始出处:
Blood, 1 April 2007, Vol. 109, No. 7, pp. 3080-3083.
Brief Report
Connective tissue growth factor (CTGF) expression and outcome in adult patients with acute lymphoblastic leukemia
Olga Sala-Torra1, Holly M. Gundacker2, Derek L. Stirewalt1, Paula A. Ladne1, Era L. Pogosova-Agadjanyan1, Marilyn L. Slovak3, Cheryl L. Willman4, Shelly Heimfeld1, David H. Boldt5, and Jerald P. Radich1
1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; 2 Statistical Center, Southwest Oncology Group, Seattle, WA; 3 Division of Pathology, City of Hope National Medical Center, Duarte, CA; 4 Department of Pathology, University of New Mexico School of Medicine, Albuquerque; 5 Medicine/Hematology University of Texas, Health Science Center at San Antonio
We compared the gene expression profile of adult acute lymphoblastic leukemia (ALL) to normal hematopoietic and non-ALL samples using oligonucleotide arrays. Connective tissue growth factor (CTGF) was the highest overexpressed gene in B-cell ALL compared with the other groups, and displayed heterogeneous expression, suggesting it might have prognostic relevance. CTGF expression was examined by quantitative reverse transcriptase–polymerase chain reaction (QRT-PCR) on 79 adult ALL specimens. CTGF expression levels were significantly increased in ALL cases with B-lineage (P < .001), unfavorable cytogenetics (P < .001), and blasts expressing CD34 (P < .001). In a multivariate proportional hazards model, higher CTGF expression levels corresponded to worsening of overall survival (OS; hazard ratio 1.36, for each 10-fold increase in expression; P = .019). Further studies are ongoing to confirm the prognostic value of CTGF expression in ALL and to investigate its role in normal and abnormal lymphocyte biology.
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