| miRNAs : Discovery of Tiny Regulatory RNAs | | 点击： 作者： 来源： 时间： 2007-03-10 本站论坛 |
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How can informatics techniques help in unraveling the mystery of miRNAs ?
"The nice thing about uncovering these many microRNAs is that it places before us a buffet of questions and research projects larger than any one group could possibly pursue." The excitement lies in these unanswered questions and new opportunities. The convergence of researchers in different disciplines sparks unanticipated collaborations to explore intriguing possibilities and the outcomes can be useful and far ranging. An area rich for collaborative investigation is in the field of genomics, which encompasses volumes of information and poses computational challenges. "We've developed and applied a way of finding many of a new class of gene s and think that in a year we may have found all of the C. elegans miRNAs. If we do, we're not focusing on one gene like we used to, but a whole class of genes," Ambros said. "We'd like to answer broad questions about how they work as well as specific questions about individual genes. The challenges escalate as the number of genes increase and the analyses become more complex. With lots of data we have to be able to weed out what is garbage and what is real: so computer tools and bioinformatics expertise are essential."
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