Maria Labandeira-Rey, Florence Couzon, Sandrine Boisset, Eric L. Brown, Michele Bes, Yvonne Benito, Elena M. Barbu, Vanessa Vazquez, Magnus Höök, Jerome Etienne, François Vandenesch, and M. Gabriela Bowden Science 23 February 2007: 1130-1133. Published online 18 January 2007 [DOI: 10.1126/science.1137165] (in Science Express Reports) A virulent form of drug-resistant bacterium not only carries genes for a potent toxin but also makes more of an inflammatory factor, exacerbating the resulting pneumonia. Abstract »| Full Text »| PDF »| Supporting Online Material »|
Regulation of Drosophila Life Span by Olfaction and Food-Derived Odors Sergiy Libert, Jessica Zwiener, Xiaowen Chu, Wayne VanVoorhies, Gregg Roman, and Scott D. Pletcher Science 23 February 2007: 1133-1137. Published online 1 February 2007 [DOI: 10.1126/science.1136610] (in Science Express Reports) In flies, the ability of a severely calorie-restricted diet to extend life span can be partially reversed by exposing the flies to the odor of their main food, yeast. Abstract »| Full Text »| PDF »| Supporting Online Material »|
Redirection of Silencing Targets by Adenosine-to-Inosine Editing of miRNAs Yukio Kawahara, Boris Zinshteyn, Praveen Sethupathy, Hisashi Iizasa, Artemis G. Hatzigeorgiou, and Kazuko Nishikura Science 23 February 2007: 1137-1140. Editing of a particular miRNA--changing adenosine to inosine--alters which mRNAs the miRNA targets for degradation, which in turn changes uric acid levels in the brain. Abstract »| Full Text »| PDF »| Supporting Online Material »|
Gene Body-Specific Methylation on the Active X Chromosome Asaf Hellman and Andrew Chess Science 23 February 2007: 1141-1143. Transcribed portions of genes on the active human X chromosome are unexpectedly hypermethylated, usually considered an inactivating mechanism at promotors. Abstract »| Full Text »| PDF »| Supporting Online Material »|
Reversal of Neurological Defects in a Mouse Model of Rett Syndrome Jacky Guy, Jian Gan, Jim Selfridge, Stuart Cobb, and Adrian Bird Science 23 February 2007: 1143-1147. Published online 8 February 2007 [DOI: 10.1126/science.1138389] (in Science Express Reports) In a mouse replica of an autism-like genetic disorder, reactivation of the defective gene after symptoms appear ameliorates the disease, suggesting a therapeutic approach. Abstract »| Full Text »| PDF »| Supporting Online Material »|
From the AAAS Office of Publishing and Member Services BUSINESS OFFICE FEATURE: Clinical Proteomics: Coming to Terms with Complexity Monya Baker Science 23 February 2007: 1149-1153. Summary »|
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