Human Catechol-O-Methyltransferase Haplotypes Modulate Protein Expression by Altering mRNA Secondary Structure
A. G. Nackley, S. A. Shabalina, I. E. Tchivileva, K. Satterfield, O. Korchynskyi, S. S. Makarov, W. Maixner, and L. Diatchenko
Science 22 December 2006: 1930-1933.
Variants of a human gene that affect pain sensitivity produce dissimilar amounts of protein because of nucleotide differences that affect mRNA secondary structure and after translation.
Abstract »| Full Text »| PDF »| Supporting Online Material »|
Lineages of Acidophilic Archaea Revealed by Community Genomic Analysis
Brett J. Baker, Gene W. Tyson, Richard I. Webb, Judith Flanagan, Philip Hugenholtz, Eric E. Allen, and Jillian F. Banfield
Science 22 December 2006: 1933-1935.
Direct cloning of an unusual 16S rRNA in biofilms from acid mine drainage reveals a distinct lineage of small archaeons that may subsist on pyrite.
Abstract »| Full Text »| PDF »| Supporting Online Material »|
Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling
Amanda L. Gavin, Kasper Hoebe, Bao Duong, Takayuki Ota, Christopher Martin, Bruce Beutler, and David Nemazee
Science 22 December 2006: 1936-1938.
Adjuvants added to vaccines boost responses, surprisingly, without acting through known innate immunity receptors, indicating a need for vaccine development strategies.
Abstract »| Full Text »| PDF »| Supporting Online Material »|
Relating Three-Dimensional Structures to Protein Networks Provides Evolutionary Insights
Philip M. Kim, Long J. Lu, Yu Xia, and Mark B. Gerstein
Science 22 December 2006: 1938-1941.
Proteins with many simultaneous partners tend to be conserved, whereas those with one partner at a time are more likely to vary among species.
Abstract »| Full Text »| PDF »| Supporting Online Material »|
Characterizing a Mammalian Circannual Pacemaker
Gerald A. Lincoln, Iain J. Clarke, Roelof A. Hut, and David G. Hazlerigg
Science 22 December 2006: 1941-1944.
Annual molting cycles in sheep are controlled by timing cells within the pituitary that trigger hormone secretion from adjacent cells.
Abstract »| Full Text »| PDF »| Supporting Online Material »|
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