Maria Labandeira-Rey, Florence Couzon, Sandrine Boisset, Eric L. Brown, Michele Bes, Yvonne Benito, Elena M. Barbu, Vanessa Vazquez, Magnus Höök, Jerome Etienne, François Vandenesch, and M. Gabriela Bowden
Science 23 February 2007: 1130-1133.
Published online 18 January 2007 [DOI: 10.1126/science.1137165] (in Science Express Reports)
A virulent form of drug-resistant bacterium not only carries genes for a potent toxin but also makes more of an inflammatory factor, exacerbating the resulting pneumonia.
Abstract »| Full Text »| PDF »| Supporting Online Material »|
Regulation of Drosophila Life Span by Olfaction and Food-Derived Odors
Sergiy Libert, Jessica Zwiener, Xiaowen Chu, Wayne VanVoorhies, Gregg Roman, and Scott D. Pletcher
Science 23 February 2007: 1133-1137.
Published online 1 February 2007 [DOI: 10.1126/science.1136610] (in Science Express Reports)
In flies, the ability of a severely calorie-restricted diet to extend life span can be partially reversed by exposing the flies to the odor of their main food, yeast.
Abstract »| Full Text »| PDF »| Supporting Online Material »|
Redirection of Silencing Targets by Adenosine-to-Inosine Editing of miRNAs
Yukio Kawahara, Boris Zinshteyn, Praveen Sethupathy, Hisashi Iizasa, Artemis G. Hatzigeorgiou, and Kazuko Nishikura
Science 23 February 2007: 1137-1140.
Editing of a particular miRNA--changing adenosine to inosine--alters which mRNAs the miRNA targets for degradation, which in turn changes uric acid levels in the brain.
Abstract »| Full Text »| PDF »| Supporting Online Material »|
Gene Body-Specific Methylation on the Active X Chromosome
Asaf Hellman and Andrew Chess
Science 23 February 2007: 1141-1143.
Transcribed portions of genes on the active human X chromosome are unexpectedly hypermethylated, usually considered an inactivating mechanism at promotors.
Abstract »| Full Text »| PDF »| Supporting Online Material »|
Reversal of Neurological Defects in a Mouse Model of Rett Syndrome
Jacky Guy, Jian Gan, Jim Selfridge, Stuart Cobb, and Adrian Bird
Science 23 February 2007: 1143-1147.
Published online 8 February 2007 [DOI: 10.1126/science.1138389] (in Science Express Reports)
In a mouse replica of an autism-like genetic disorder, reactivation of the defective gene after symptoms appear ameliorates the disease, suggesting a therapeutic approach.
Abstract »| Full Text »| PDF »| Supporting Online Material »|
From the AAAS Office of Publishing and Member Services
BUSINESS OFFICE FEATURE: Clinical Proteomics: Coming to Terms with Complexity
Monya Baker
Science 23 February 2007: 1149-1153.
Summary »|
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