Jeffrey W. Dalley, Tim D. Fryer, Laurent Brichard, Emma S. J. Robinson, David E. H. Theobald, Kristjan Lääne, Yolanda Peña, Emily R. Murphy, Yasmene Shah, Katrin Probst, Irina Abakumova, Franklin I. Aigbirhio, Hugh K. Richards, Young Hong, Jean-Claude Baron, Barry J. Everitt, and Trevor W. Robbins
Science 2 March 2007: 1267-1270.
Rats that tend to abuse cocaine have lower dopamine receptor availability even before drug exposure, suggesting that this trait is preexisting and not a result of drug abuse.
Abstract »| Full Text »| PDF »| Supporting Online Material »|
Reconstitution of DNA Segregation Driven by Assembly of a Prokaryotic Actin Homolog
Ethan C. Garner, Christopher S. Campbell, Douglas B. Weibel, and R. Dyche Mullins
Science 2 March 2007: 1270-1274.
DNA movement during prokaryotic cell division can be reconstituted in a cell-free system by an actin-like protein and a DNA binding protein, which form a bipolar spindle.
Abstract »| Full Text »| PDF »| Supporting Online Material »|
Multiple Functions of the IKK-Related Kinase IKK in Interferon-Mediated Antiviral Immunity
Benjamin R. tenOever, Sze-Ling Ng, Mark A. Chua, Sarah M. McWhirter, Adolfo García-Sastre, and Tom Maniatis
Science 2 March 2007: 1274-1278.
A kinase activated in response to viral infection unexpectedly acts directly on a transcription factor for antiviral genes.
Abstract »| Full Text »| PDF »| Supporting Online Material »|
LRP6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors
Arya Mani, Jayaram Radhakrishnan, He Wang, Alaleh Mani, Mohammad-Ali Mani, Carol Nelson-Williams, Khary S. Carew, Shrikant Mane, Hossein Najmabadi, Dan Wu, and Richard P. Lifton
Science 2 March 2007: 1278-1282.
A mutation in a key signaling pathway causes both coronary artery disease and a metabolic syndrome, explaining why these disorders are often associated with one another.
Abstract »| Full Text »| PDF »| Supporting Online Material »|
Emulating Membrane Protein Evolution by Rational Design
Mikaela Rapp, Susanna Seppälä, Erik Granseth, and Gunnar von Heijne
Science 2 March 2007: 1282-1284.
Published online 25 January 2007 [DOI: 10.1126/science.1135406] (in Science Express Reports)
Stepwise modifications to a drug efflux pump show how the bacterial dimeric pump may have evolved through duplication and inversion of an ancestral protein domain.
Abstract »| Full Text »| PDF »| Supporting Online Material »|
Local Interactions Select for Lower Pathogen Infectivity
Michael Boots and Michael Mealor
Science 2 March 2007: 1284-1286.
Among caterpillars harboring a virus, the least mobile individuals harbor the least infective viruses, confirming a basic hypothesis about disease transmission.
Abstract »| Full Text »| PDF »| Supporting Online Material »|
Technical Comments
Comment on "Detecting Awareness in the Vegetative State"
Parashkev Nachev and Masud Husain
Science 2 March 2007: 1221.
Abstract »| Full Text »| PDF »|
Comment on "Detecting Awareness in the Vegetative State"
Daniel L. Greenberg
Science 2 March 2007: 1221.
Abstract »| Full Text »| PDF »|
Response to Comments on "Detecting Awareness in the Vegetative State"
Adrian M. Owen, Martin R. Coleman, Melanie Boly, Matthew H. Davis, Steven Laureys, Dietsje Jolles, and John D. Pickard
Science 2 March 2007: 1221.
Abstract »| Full Text »| PDF »|
From the AAAS Office of Publishing and Member Services
BUSINESS OFFICE FEATURE: Europe's Brain Gain
Gunjan Sinha
Science 2 March 2007: 1289-1295.
Summary »|
