The age of chance p376
Arthur Fine reviews Uncertainty: Einstein, Heisenberg, Bohr, and the Struggle for the Soul of Science by David Lindley
doi:10.1038/446376a
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Poisoned at work p377
Anthony Robbins reviews How Everyday Products Make People Sick: Toxins at Home and in the Workplace by Paul D. Blanc
doi:10.1038/446377a
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Top of pageEssay
Connections
Frontier at your fingertips p379
Between the nano- and micrometre scales, the collective behaviour of matter can give rise to startling emergent properties that hint at the nexus between biology and physics.
Piers Coleman
doi:10.1038/446379a
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Top of pageNews and Views
Mechanochemistry: A reaction to stress p381
Chemists usually kick-start reactions with heat, light or electricity, but a far less common option is to use mechanical stress. It now seems that stress not only triggers reactions, but can also direct their course.
Brad M. Rosen and Virgil Percec
doi:10.1038/446381a
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Asteroids: Spun in the sun p382
Two asteroids have been observed gradually spinning faster and faster, and the hot tip is that sunlight is the cause. If so, this could give us a handle on the dynamics and evolution of the asteroid belt in general.
William F. Bottke
doi:10.1038/nature05711
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Organic chemistry: Synthesis undressed p383
Fragile chemical groups can be shielded from harsh reaction conditions by temporary protection. This approach is conventional wisdom for organic synthesis, but is it always the best solution?
John A. Porco, Jr
doi:10.1038/446383a
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Behavioural neuroscience: Hare-brained flies p385
Sadaf Shadan
doi:10.1038/446385a
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Evolutionary biology: Adaptation under a microscope p386
Experiments with microorganisms can guide thinking about the big questions being tackled by evolutionary biologists — for instance, how predation and immigration might play a role in adaptive radiation.
Rosemary G. Gillespie and Brent C. Emerson
doi:10.1038/446386a
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Biochemistry: Molecular cannibalism p387
The biosynthesis of vitamin B12 has fascinated generations of scientists, but part of the pathway was unknown. The missing enzymatic link has now been found, only to raise more mechanistic questions.
Steven E. Ealick and Tadhg P. Begley
doi:10.1038/446387a
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50 & 100 Years Ago p387
doi:10.1038/446387b
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Obituary: Alan Graham MacDiarmid (1927–2007) p390
Pioneer of conducting polymers, and proud Antipodean.
Andrew Holmes
doi:10.1038/446390a
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Top of pageNews and Views Q&A
Organometallic chemistry: C–H activation p391
The stability of the chemical bonds in saturated hydrocarbons makes them generally unreactive. But the invention of processes in which carbon–hydrogen (C–H) bonds in hydrocarbons can be activated is allowing chemists to exploit organic compounds in previously unimaginable ways.
Robert G. Bergman
doi:10.1038/446391a
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Top of pageReview
Relativistic effects in homogeneous gold catalysis p395
David J. Gorin and F. Dean Toste
doi:10.1038/nature05592
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Top of pageArticles
Total synthesis of marine natural products without using protecting groups p404
Phil S. Baran, Thomas J. Maimone and Jeremy M. Richter
doi:10.1038/nature05569
Abstract | Full Text | PDF (463K) | Supplementary information
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Skew of mantle upwelling beneath the East Pacific Rise governs segmentation p409
Douglas R. Toomey, David Jousselin, Robert A. Dunn, William S. D. Wilcock and R. S. Detrick
doi:10.1038/nature05679
Abstract | Full Text | PDF (517K) | Supplementary information
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Autocatalytic cleavage of Clostridium difficile toxin B p415
Jessica Reineke, Stefan Tenzer, Maja Rupnik, Andreas Koschinski, Oliver Hasselmayer, André Schrattenholz, Hansjörg Schild and Christoph von Eichel-Streiber
doi:10.1038/nature05622
Abstract | Full Text | PDF (919K) | Supplementary information
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Top of pageLetters
Acceleration of the rotation of asteroid 1862 Apollo by radiation torques p420
Mikko Kaasalainen, Josef urech, Brian D. Warner, Yurij N. Krugly and Ninel M. Gaftonyuk
doi:10.1038/nature05614
First paragraph | Full Text | PDF (325K) | Supplementary information
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Biasing reaction pathways with mechanical force p423
Charles R. Hickenboth, Jeffrey S. Moore, Scott R. White, Nancy R. Sottos, Jerome Baudry and Scott R. Wilson
doi:10.1038/nature05681
First paragraph | Full Text | PDF (642K) | Supplementary information
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Seismic evidence for convection-driven motion of the North American plate p428
David W. Eaton and Andrew Frederiksen
doi:10.1038/nature05675
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The effects of competition and predation on diversification in a model adaptive radiation p432
Justin R. Meyer and Rees Kassen
doi:10.1038/nature05599
First paragraph | Full Text | PDF (230K) | Supplementary information
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Immigration history controls diversification in experimental adaptive radiation p436
Tadashi Fukami, Hubertus J. E. Beaumont, Xue-Xian Zhang and Paul B. Rainey
doi:10.1038/nature05629
First paragraph | Full Text | PDF (295K) | Supplementary information
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Relating ligand binding to activation gating in CNGA2 channels p440
Christoph Biskup, Jana Kusch, Eckhard Schulz, Vasilica Nache, Frank Schwede, Frank Lehmann, Volker Hagen and Klaus Benndorf
doi:10.1038/nature05596
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p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload p444
Masanori Sano, Tohru Minamino, Haruhiro Toko, Hideyuki Miyauchi, Masayuki Orimo, Yingjie Qin, Hiroshi Akazawa, Kaoru Tateno, Yosuke Kayama, Mutsuo Harada, Ippei Shimizu, Takayuki Asahara, Hirofumi Hamada, Shuhei Tomita, Jeffrey D. Molkentin, Yunzeng Zou and Issei Komuro
doi:10.1038/nature05602
First paragraph | Full Text | PDF (681K) | Supplementary information
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BluB cannibalizes flavin to form the lower ligand of vitamin B12 p449
Michiko E. Taga, Nicholas A. Larsen, Annaleise R. Howard-Jones, Christopher T. Walsh and Graham C. Walker
doi:10.1038/nature05611
First paragraph | Full Text | PDF (2,045K) | Supplementary information
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Peptide bond formation destabilizes Shine–Dalgarno interaction on the ribosome p454
Sotaro Uemura, Magdalena Dorywalska, Tae-Hee Lee, Harold D. Kim, Joseph D. Puglisi and Steven Chu
doi:10.1038/nature05625
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Stepwise protein-mediated RNA folding directs assembly of telomerase ribonucleoprotein p458
Michael D. Stone, Mariana Mihalusova, Catherine M. O'Connor, Ramadevi Prathapam, Kathleen Collins and Xiaowei Zhuang
doi:10.1038/nature05600
First paragraph | Full Text | PDF (321K) | Supplementary information
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Top of pageNaturejobs
Prospect
Prospects p463
The course of true love never did run smooth.
Paul Smaglik
doi:10.1038/nj7134-463a
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Careers and Recruitment
Chemistry in context p464
Rumours of the demise of chemistry are misplaced — the 'science of everything' prevails, if sometimes under new guises. Ricki Lewis reports.
Ricki Lewis
doi:10.1038/nj7134-464a
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Career Views
David Schimel, chief executive, National Ecological Observatory Network, Washington DC p466
David Schimel takes the reins at the National Ecological Observatory Network
Matthew Nestel
doi:10.1038/nj7134-466a
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Researchers without frontiers p466
Marie Curie fellows seek maximum mobility.
Vanessa Díaz & Guggi Kofod
doi:10.1038/nj7134-466b
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Beginner's luck p466
I actually seem to be enjoying my postdoc.
Peter Jordan
doi:10.1038/nj7134-466c
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Recruiters
The inside track from academia and industry: Staying power p468
Carving out a successful career as an academic is hard, but there are steps you can take to ease your way.
Moray Campbell
doi:10.1038/nj7134-468a
Full Text | PDF (76K)
