November 16, 2006
H5N1病毒的Haemagglutin上的两处突变
在亚洲、欧洲和非洲流行的H5N1禽流感病毒不能与人类细胞受体结合的事实，帮助防止了该病毒引起一场这种疾病的人类变种的全球大流行。现在，对从被感染的少数人（来自越南和泰国）身上分离出的H5N1病毒所做的一项研究工作，在结合受体的病毒Haemagglutin的第182号位置和第192号位置发现了两处突变，这两处突变使其与人类和禽类受体都能结合。这些突变也许可用作分子标记，来评估H5N1野外分离种的流行潜力。
November 16, 2006
蛋白相互作用的核磁共振观测研究
大量生物过程中涉及蛋白-蛋白相互作用，尽管X-射线晶体学方法和核磁共振光谱方法可用来研究一种复合物中的两个（或更多）蛋白，但难以确定这两个蛋白在形成该最终复合物之前是怎样相互作用的。现在，研究人员利用核磁共振光谱方法，对细菌磷酸转移酶体系（enzyme I的N-端区域和phosphocarrier蛋白HPr）中的第一种二元复合物的瞬态的、非特定结合的复合分子组合体进行了直接观测，所取得的一项重要发现是，这些被称为“encounter complexes”的复合物的分布与蛋白表面上的静电电势相关联。
Editorials
Congressional agendas p243
A US Congress newly dominated by Democrats needs to exercise financial restraint. Manned spaceflight is a good candidate for cuts, and energy research needs belated leadership.
doi:10.1038/444243a
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Order for microbes p243
Burgeoning microbial gene data require coherent efforts to make them readily usable.
doi:10.1038/444243b
Full Text | PDF (120K)
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Success and successor p244
Exit an outstanding science minister; enter a more political operator.
doi:10.1038/444244a
Full Text | PDF (82K)
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Top of pageResearch Highlights
Research highlights p246
doi:10.1038/444246a
Full Text | PDF (359K)
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Top of pageNews
The politics of breathing p248
Both sides in a US pollution dispute claim that science is on their side. Emma Marris explains how environmental laws have forced them into this position.
doi:10.1038/444248a
Full Text | PDF (341K)
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WHO boss faces test of independence p250
China's candidate secures top job at health agency.
Declan Butler
doi:10.1038/444250a
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Q&A: Bart Gordon p251
The incoming chair of the House Committee on Science sets out his stall.
Emma Maris
doi:10.1038/444251a
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Sidelines p251
doi:10.1038/444251b
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UK civil servants accused of warping science p252
Politicians criticized for 'cherry-picking' evidence.
Jim Giles
doi:10.1038/444252a
Full Text | PDF (323K)
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Gunmen seize academics at Baghdad ministry p252
Iraq rocked by mass kidnap at institute
Jim Giles and Declan Butler
doi:10.1038/444252b
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German stem-cell law under fire p253
Funding agency calls for relaxation of research rules.
Alison Abbott
doi:10.1038/444253a
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Neanderthal genome sees first light p254
Initial sequences sheds light on common ancestor.
Rex Dalton
doi:10.1038/444254a
Full Text | PDF (168K)
See also: Editor's summary
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News in brief p255
doi:10.1038/444255a
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Top of pageBusiness
The chips are down p256
Geneticists' desire to track the roots of complex diseases has shaken up the market for gene chips. Meredith Wadman reports on two firms jostling for position in a business potentially worth US$500 million.
doi:10.1038/444256a
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In brief p257
doi:10.1038/444257a
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Market watch p257
doi:10.1038/444257b
Full Text | PDF (114K)
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