Volume 439 Number 7074 pp243-368封面故事:纳米磁体阵列做成的人工“自旋冰”当一个系统中有若干相互作用进行竞争时,它们不可能都取得胜利,所以分辨“落败”者是决定一个系统整体行为的一个重要决定因素。具体来说,在磁系统中,自旋作用中的几何挫败会导致出现“自旋冰”这样的奇怪效应。所谓“自旋冰”,指的是原子磁矩模仿水冰中氢离子位置的受挫情况的一种状态。现在,研究人员利用通过平板印刷方式获得的纳米磁体阵列生成了人工“自旋冰”。利用这个模型,就有可能来非常详细地研究受挫情况。这种研究对于磁记录应用是有意义的。在磁记录应用中,铁磁性元件的密度在不断地增加。本期封面所示为在磁力显微镜下看到的人工自旋冰的磁化图案:图上“高原”和“峡谷”代表相反的磁化区域。
“微RNA”的功能(A little learning)“微RNA”(MicroRNA)是基因表达的重要调控物质,在细胞死亡和葡萄糖动态平衡等各种不同过程中发挥一定作用。研究人员已经从脊椎动物神经系统中分离出了若干种“微RNA”,但对它们的功能却知之甚少。现在,对细胞培养物的海马体神经元所做的一项研究显示,miR-134(一种大脑特有的“微RNA”)抑制一种蛋白的表达,该蛋白促进树状脊的生长,它们是从代表来自相邻神经元的联会输入点的神经过程产生的突出结构。树状脊的大小是联会强度的一个指示,所以这表明,“微RNA”参与了与学习和记忆有关的联会强度的长久变化。
科学家找到脱落酸的一种生理受体脱落酸是一种参与压力响应的主要植物激素,包括休眠和叶落(其名称由此而来)过程。 20多年来,研究人员一直在寻找脱落酸的一种生理受体。现在,Razem等人已经找到一个。FCA是一种调控开花时间的RNA结合蛋白,它以高亲和力与脱落酸结合。脱落酸对由FCA引导的mRNA的处理过程施加直接控制。在植物和动物中有很多尚未定性的RNA结合蛋白,这一控制机制的发现表明,它们中的一些可能参与了由激素调节的转录后基因调控
星际尘埃颗粒的来源地球不断被直径达一毫米的星际尘埃颗粒(IDP)轰击,它们是在碰撞或碎裂过程中从小行星和彗星中释放出来的。这些颗粒中富含氦-3同位素的事实意味着,IDP流入量的峰值可以在地质记录中找到。通过对海床沉积物中的氦-3进行新的测定,再加上数值模拟,研究人员发现,在晚中新世一个150万年的时期来到地球上的星际尘埃几乎只有一个来源,那就是太阳系中的单一一次事件。这次事件似乎是,大约在800万年前,一个直径为150公里的小行星被碰撞毁掉了,这次碰撞就是产生Veritas小行星家族的同一次碰撞。有趣的是,这次尘埃积累过程的高峰与中新世期间不是很强的变冷事件在时间上巧合,但这两个现象之间的因果关系仍然只是一种猜测。
银-94能同时进行单质子和双质子衰变一种以前不知道的放射性衰变行为已在一种奇异的银同位素中被发现。这种银同位素即银-94,它的原子通过一个质子和两个质子的衰变两种方式来丢掉质子。质子比例异常高的原子核可以通过一个一个地发射质子来衰变,这是1982年首次在镥-151中看到的一个反应。20年后,铁和锌的富含质子的同位素被发现通过同时发射两个质子的方式来衰变。银-94同时采用这两种方式衰变:一个质子的衰变报告于2005年,衰变产物为一个钯同位素(钯-93);现在又观测到了两个质子的衰变,衰变产物为一个铑同位素(铑-92)。单个质子被优先从雪茄形分子的“端部”发射出去。在双质子衰变中,两个质子既可以从同一端一起发射,也可以分别从两端发射。
脊椎动物中耳与鱼腮在演化上的关系对名为Panderichthys的鱼(一种与最早的两栖动物亲缘关系密切的长着圆鳍的鱼)所做的详细研究表明,脊椎动物中耳演化的早期阶段与呼吸、而不是与探听声音有关。我们的中耳相应于一个缩小了的腮缝,在鱼类中被称为“气门”。在一个由位于里加的“拉脱维亚自然历史博物馆”收藏的保存完好的Panderichthys化石中,这种腮缝要比其他古代鱼类身上的腮缝大得多,具有脊椎动物一样的构造,但很可能是用来吸水或吸空气的。镫骨和中耳其他构成部分在听觉系统中的基本作用,最初似乎是在原始的陆地脊椎动物中形成的。
海洋中叶绿素含量最大的深水层在海洋中很多地方,随着各种不同相反的现象达成一个平衡状态,在距表面50-100米深的地方会形成一个被称为“叶绿素含量最大的深水层”。从表面海水向下沉降、并带去养分的浮游植物会遇到一个向上的养分流,从而在距海平面有一定深度、但仍有充足光线的地方供给新的生物生长。这些叶绿素含量很高的深水层在海洋每年的生产中以及在碳向海洋内部的流动中都扮演一个重要角色。一项新的研究表明,降低垂直方向上的混合作用,能通过产生这些叶绿素含量最大的深水层的过程在时间尺度上的一种错误匹配,在这些深水层中的浮游植物生物量和物种组成上诱发振荡和混沌。这一发现与被人们普遍接受的一种观点是矛盾的,该观点认为,叶绿素含量最大的深水层是稳定的,它们跟踪光照和养分状况的季节变化。气候变化模型预测,全球变暖将抑制海洋中垂直方向的混合作用,这有可能使叶绿素含量最大的深水层中的浮游植物动态失去平衡,并对海洋初级生产、浮游植物物种组成和碳输出产生影响。
Bardet-Biedl综合症中的“异位显性”现象“异位显性”是一种生物现象,即一个基因抑制或增强位于不同位点的另一个基因的表达。该现象是基因变化的一个重要来源,但此前研究人员对其中涉及的机制却没有进行详细分析。现在,Badano等人成功演示和仔细分析了Bardet-Biedl综合症的“异位显性”现象。这种综合症的常见症状是肥胖和学习缺陷,症状的严重程度在不同患者之间差别非常大,与不同基因上发生的突变的不同组合有关。一个被称为MGC1203的修饰基因与在Bardet-Biedl综合症中发生突变的其他基因进行相互作用,导致出现该疾病的一种更严重形式。这个基因本身的突变不大可能引起该疾病。
关于RNA病毒复制的“准种”假设得到实验支持RNA病毒的复制与在以DNA为遗传材料的生物中实际突变率高于所看到的突变率有关。该现象能生成不能存活的个体,但正如曾有人提出的那样,也能产生一些有用的变化,这些变化也许能增强病毒种群的适应性,因为这些变化能让它们适应在感染过程中碰到的变化的环境。此前,这种被称为“准种”假设的观点没有实验支持。但现在,一项寻找能够非常准确地复制自己基因组的病毒的研究工作,为这一思想提供了支持。携带一种“超准确”RNA聚合酶的脊髓灰质炎病毒分离种群比正常病毒变异更小,感染能力更差。这些结果对抗病毒药物的开发可能有参考价值。
分子肿瘤摸底研究的重大进展分子肿瘤摸底研究是寻找有效的肿瘤治疗目标和开发有效的癌症治疗方法的一种方式。两个小组在本期Nature上报告了他们在这一方向上所取得的重大进展。Bild等人研究了反映各种不同的致癌基因信号传导通道的激发情况的基因表达模式。利用这些通道特征的组合,他们能够预测哪些乳腺癌、卵巢癌或肺癌患者预后比较差。以这种方式识别在某种特定类型的癌症中失控的分子通道的能力,也许可用来预测该类型的癌症对特定治疗药物的灵敏度。Solit等人研究了RAS 和 BRAF基因发生突变(被认为至少部分是通过激发MEK/ERK信号通道来引发癌症的)的肿瘤细胞。他们发现,有BRAF突变、但却没有RAS突变的肿瘤对PD0325901高度敏感。PD0325901是一种MEK抑制因子,正在用黑素瘤、结肠癌、乳腺癌和肺癌患者进行早期临床试验。所以,通过检验BRAF突变是否存在,也许可以识别出哪些患者最有可能受益于这种类型的药物。
Editorials
Standards for papers on cloning p243
In the wake of the Hwang scandal, journals have been reviewing their refereeing procedures. Following a survey of experts, here are Nature's thoughts on papers about cloning, with an invitation to comment.
doi:10.1038/439243a
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A new ERA? p244
A novel component of the European Research Area will require national funders' cooperation.
doi:10.1038/439244a
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Circulation challenge p244
The lack of monitoring of ocean currents must be addressed quickly.
doi:10.1038/439244b
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Top of pageResearch Highlights
Research highlights p246
doi:10.1038/439246a
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Top of pageNews
Alarms ring over bird flu mutations p248
Turkish virus shows increased affinity for humans.
Declan Butler
doi:10.1038/439248a
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Doctor admits Lancet study is fiction p248
Faked data keeps spotlight on peer review.
Emma Marris
doi:10.1038/439248b
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Will Germany choose a fair élite? p249
Contest to select top universities accused of political bias.
doi:10.1038/439249a
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Astronomers told to cut it out p250
US observatories face battle for survival.
Geoff Brumfiel
doi:10.1038/439250a
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Snapshot: Cloudshine is a stellar snap for Harvard duo p250
Gas clouds in starlight captured on camera.
doi:10.1038/439250b
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Sidelines p252
doi:10.1038/439252a
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Journals submit to scrutiny of their peer-review process p252
Largest-ever study gains unprecedented access.
Jim Giles
doi:10.1038/439252b
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Promises to clean up industry fail to convince p253
Environmentalists unimpressed by companies' voluntary standards.
Carina Dennis
doi:10.1038/439253a
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Stress makes medics ever gloomier p254
US medical schools have high incidence of clinical depression.
Helen Pearson
doi:10.1038/439254a
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News in brief p255
doi:10.1038/439255a
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Correction p255
doi:10.1038/439255b
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Top of pageNews Features
Climate change: A sea change p256
A collapse in ocean currents triggered by global warming could be catastrophic, but only now is the Atlantic circulation being properly monitored. Quirin Schiermeier investigates.
doi:10.1038/439256a
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Palaeontology: Hooked on fossils p262
For decades, much of the early history of fish evolution was locked away in rocks in China. Rex Dalton tracks down the scientist who brought many of the remains to the surface.
doi:10.1038/439262a
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Top of pageBusiness
Hwang scandal hits Korean biotech hard p265
Ichiko Fuyuno
doi:10.1038/439265a
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In brief p265
doi:10.1038/439265b
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Top of pageCorrespondence
Risks of resurrecting 1918 flu virus outweigh benefits p266
Dr Jan van Aken
doi:10.1038/439266a
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Value of high-protein diet is clearer than drawbacks p266
Peter Clifton
doi:10.1038/439266b
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Saintly helpers at hand in Renaissance hospital art p266
Piero Dolara
doi:10.1038/439266c
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Humour of gene names lost in translation to patients p266
Ken Maclean
doi:10.1038/439266d
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Top of pageCommentary
Experiments in social responsibility p267
Pursuing drugs for neglected diseases is not a traditional part of the pharmaceutical company portfolio. But Paul Herrling of Novartis finds that it brings welcome changes both within and outside the industry.
doi:10.1038/439267a
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Top of pageBooks and Arts
Experimental fiction p269
Publishers could do a lot more to promote 'lab lit', a genre of novel set in the world of science.
Jennifer Rohn
doi:10.1038/439269a
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Exhibition: Geological fireworks p270
doi:10.1038/439270a
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Living with infection p270
Tony McMichael reviews Diseases and Human Evolution by Ethne Barnes
doi:10.1038/439270b
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Unearthing religion p271
Nicholas J. Conard reviews Inside the Neolithic Mind: Consciousness, Cosmos and the Realm of the Gods by David Lewis-Williams and David Pearce
doi:10.1038/439271a
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Top of pageNews and Views
Condensed-matter physics: Great moments in disorder p273
An array of nanomagnets has been designed to resemble the disordered magnetic state known as 'spin ice'. This could transform our understanding of disordered matter and, potentially, lead to new technologies.
Steven T. Bramwell
doi:10.1038/439273a
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Cancer biology: Signatures guide drug choice p274
Cancer drugs are increasingly designed to target specific cell-signalling pathways. When, and in what combination, these drugs should be used might be judged by analysing the gene expression signature of the tumour.
Julian Downward
doi:10.1038/439274a
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Atmospheric chemistry: Biogenic bromine p275
Among other effects, bromine released by biological processes in the oceans apparently reduces ozone levels in the troposphere. This source may be a link between atmospheric composition and climate change.
Ross J. Salawitch
doi:10.1038/439275a
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Plant biology: Abscisic acid in bloom p277
To survive environmental stresses, plants must respond to the hormone abscisic acid. The receptors for this hormone have remained elusive, but one receptor with unique functions in flowering has now been identified.
Julian I. Schroeder and Josef M Kuhn
doi:10.1038/439277a
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50 & 100 years ago p277
doi:10.1038/439277b
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Chemical ecology: In defence of maize p278
Tim Lincoln
doi:10.1038/439278a
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Nuclear physics: Odd couple decays p279
The decay of proton-rich nuclei by the emission of a single proton has been known about for some time, and is well understood. The latest observation of two-proton emission, however, will provoke some head-scratching.
Juha Äystö
doi:10.1038/439279a
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Obituary: Theodore H. Bullock (1915–2005) p280
Trailblazer in neurobiology.
Günther K. H. Zupanc
doi:10.1038/439280a
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Top of pageBrief Communications
Superplastic carbon nanotubes p281
Conditions have been discovered that allow extensive deformation of rigid single-walled nanotubes.
J. Y. Huang, S. Chen, Z. Q. Wang, K. Kempa, Y. M. Wang, S. H. Jo, G. Chen, M. S. Dresselhaus and Z. F. Ren
doi:10.1038/439281a
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Top of pageArticles
A brain-specific microRNA regulates dendritic spine development p283
Gerhard M. Schratt, Fabian Tuebing, Elizabeth A. Nigh, Christina G. Kane, Mary E. Sabatini, Michael Kiebler and Michael E. Greenberg
doi:10.1038/nature04367
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The RNA-binding protein FCA is an abscisic acid receptor p290
Fawzi A. Razem, Ashraf El-Kereamy, Suzanne R. Abrams and Robert D. Hill
doi:10.1038/nature04373
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Top of pageLetters
A late Miocene dust shower from the break-up of an asteroid in the main belt p295
Kenneth A. Farley, David Vokrouhlický, William F. Bottke and David Nesvorný
doi:10.1038/nature04391
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Proton–proton correlations observed in two-proton radioactivity of 94Ag p298
Ivan Mukha, Ernst Roeckl, Leonid Batist, Andrey Blazhev, Joachim Döring, Hubert Grawe, Leonid Grigorenko, Mark Huyse, Zenon Janas, Reinhard Kirchner, Marco La Commara, Chiara Mazzocchi, Sam L. Tabor and Piet Van Duppen
doi:10.1038/nature04453
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Artificial 'spin ice' in a geometrically frustrated lattice of nanoscale ferromagnetic islands p303
R. F. Wang, C. Nisoli, R. S. Freitas, J. Li, W. McConville, B. J. Cooley, M. S. Lund, N. Samarth, C. Leighton, V. H. Crespi and P. Schiffer
doi:10.1038/nature04447
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Dynamical fracture instabilities due to local hyperelasticity at crack tips p307
Markus J. Buehler and Huajian Gao
doi:10.1038/nature04408
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Low sea level rise projections from mountain glaciers and icecaps under global warming p311
Sarah C. B. Raper and Roger J. Braithwaite
doi:10.1038/nature04448
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Thallium isotopic evidence for ferromanganese sediments in the mantle source of Hawaiian basalts p314
Sune G. Nielsen, Mark Rehkämper, Marc D. Norman, Alex N. Halliday and Darrell Harrison
doi:10.1038/nature04450
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Tetrapod-like middle ear architecture in a Devonian fish p318
Martin D. Brazeau and Per E. Ahlberg
doi:10.1038/nature04196
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Reduced mixing generates oscillations and chaos in the oceanic deep chlorophyll maximum p322
Jef Huisman, Nga N. Pham Thi, David M. Karl and Ben Sommeijer
doi:10.1038/nature04245
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Dissection of epistasis in oligogenic Bardet–Biedl syndrome p326
Jose L. Badano, Carmen C. Leitch, Stephen J. Ansley, Helen May-Simera, Shaneka Lawson, Richard Alan Lewis, Philip L. Beales, Harry C. Dietz, Shannon Fisher and Nicholas Katsanis
doi:10.1038/nature04370
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DNA sequence and analysis of human chromosome 8 p331
Chad Nusbaum, Tarjei S. Mikkelsen, Michael C. Zody, Shuichi Asakawa, Stefan Taudien, Manuel Garber, Chinnappa D. Kodira, Mary G. Schueler, Atsushi Shimizu, Charles A. Whittaker, Jean L. Chang, Christina A. Cuomo, Ken Dewar, Michael G. FitzGerald, Xiaoping Yang, Nicole R. Allen, Scott Anderson, Teruyo Asakawa, Karin Blechschmidt, Toby Bloom, Mark L. Borowsky, Jonathan Butler, April Cook, Benjamin Corum, Kurt DeArellano, David DeCaprio, Kathleen T. Dooley, Lester Dorris, III, Reinhard Engels, Gernot Glöckner, Nabil Hafez, Daniel S. Hagopian, Jennifer L. Hall, Sabine K. Ishikawa, David B. Jaffe, Asha Kamat, Jun Kudoh, Rüdiger Lehmann, Tashi Lokitsang, Pendexter Macdonald, John E. Major, Charles D. Matthews, Evan Mauceli, Uwe Menzel, Atanas H. Mihalev, Shinsei Minoshima, Yuji Murayama, Jerome W. Naylor, Robert Nicol, Cindy Nguyen, Sinéad B. O'Leary, Keith O'Neill, Stephen C. J. Parker, Andreas Polley, Christina K. Raymond, Kathrin Reichwald, Joseph Rodriguez, Takashi Sasaki, Markus Schilhabel, Roman Siddiqui, Cherylyn L Smith, Tam P. Sneddon, Jessica A. Talamas, Pema Tenzin, Kerri Topham, Vijay Venkataraman, Gaiping Wen, Satoru Yamazaki, Sarah K. Young, Qiandong Zeng, Andrew R. Zimmer, Andre Rosenthal, Bruce W. Birren, Matthias Platzer, Nobuyoshi Shimizu and Eric S. Lander
doi:10.1038/nature04406
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Top-down gain control of the auditory space map by gaze control circuitry in the barn owl p336
Daniel E. Winkowski and Eric I. Knudsen
doi:10.1038/nature04411
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Constant darkness is a circadian metabolic signal in mammals p340
Jianfa Zhang, Krista Kaasik, Michael R. Blackburn and Cheng Chi Lee
doi:10.1038/nature04368
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Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population p344
Marco Vignuzzi, Jeffrey K. Stone, Jamie J. Arnold, Craig E. Cameron and Raul Andino
doi:10.1038/nature04388
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Oscillations of cyclic AMP in hormone-stimulated insulin-secreting -cells p349
Oleg Dyachok, Yegor Isakov, Jenny Sågetorp and Anders Tengholm
doi:10.1038/nature04410
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Oncogenic pathway signatures in human cancers as a guide to targeted therapies p353
Andrea H. Bild, Guang Yao, Jeffrey T. Chang, Quanli Wang, Anil Potti, Dawn Chasse, Mary-Beth Joshi, David Harpole, Johnathan M. Lancaster, Andrew Berchuck, John A. Olson, Jr, Jeffrey R. Marks, Holly K. Dressman, Mike West and Joseph R. Nevins
doi:10.1038/nature04296
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BRAF mutation predicts sensitivity to MEK inhibition p358
David B. Solit, Levi A. Garraway, Christine A. Pratilas, Ayana Sawai, Gad Getz, Andrea Basso, Qing Ye, Jose M. Lobo, Yuhong She, Iman Osman, Todd R. Golub, Judith Sebolt-Leopold, William R. Sellers and Neal Rosen
doi:10.1038/nature04304
First paragraph | Full Text | PDF (530K) | Supplementary information
See also: Editor's summary | News and Views by Downward
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Top of pageNaturejobs
Prospect
Speaking in tongues p363
Host institutes should make foreign students feel more at home.
Paul Smaglik
doi:10.1038/nj7074-363a
Full Text | PDF (151K)
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Special Report
Dream big p364
Being an astronaut, video-game designer or museum curator may be every child scientist's dream. Kendall Powell talks to the creative scientists who followed the fantasy.
Kendall Powell
doi:10.1038/nj7074-364a
Full Text | PDF (518K)
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Career Views
Philip Bucksbaum, director, Stanford Ultrafast Science Center, Stanford, California p366
Virginia Gewin
doi:10.1038/nj7074-366a
Full Text | PDF (137K)
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Back to high school p366
Marilyn Brodie
doi:10.1038/nj7074-366b
Full Text | PDF (138K)
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The winding road p366
Tshaka Cunningham
doi:10.1038/nj7074-366c
Full Text | PDF (138K)
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Top of pageFutures
For he on honeydew hath fed... p368
...and drunk the milk of Paradise.
Paul Smaglik
doi:10.1038/439368a
Full Text | PDF (351K)