December 08, 2005 Nature, vol. 438, no.7069
封面故事：狗的基因组完成测序
从遗传上来讲，家狗的基因组在地球上5500种哺乳动物中可以说是最有趣的。不同品种的狗之间在行为和体征方面的明显差异（这些特征是由在相对较短的时间内人类的强化选择造成的），这意味着，狗的基因组含有了解基因组演化和组织的关键线索，也含有了解疾病易感性的线索。在本期Nature上，Lindblad-Toh等人发表了狗基因组的高质量序列草图，更具体地说，是一只名叫“塔莎”的、品种为“拳击手”的德国母狗的基因组，并且还列出了不同品种的狗之间的一些遗传差异。将狗与人类和啮齿类动物所做的比较分析，为我们提供了一个关于基因和基因组的演化的具有普遍性的视角。
狗为什么比人更适合在弯道奔跑？
在200米短跑中，没有运动员想要一条内线。为了补偿有效体重的增加 （在跑步过程中身体会受到引力和向心力加速的影响），运动员要增加每只脚着地的时间，并且必须跑慢点。而在弯道奔跑的狗就没有这种问题。在绕一个角度较小的弯道奔跑时，灰狗的四肢所承受的力比人高65%，因为狗会将其四肢与地面的接触时间保持不变。与人不同的是，灰狗是通过围绕臀部的扭动力来使身体往前跑的，所以，就像登自行车的人一样，提供跑动力的肌肉被机械地与支撑体重的结构分开了。
霍乱弧菌的生存之道
霍乱弧菌（Vibrio cholerae）占据两个形成对比的生存环境：人的小肠和水生生态环境。现在，研究人员发现了在这两个环境中都能增强该细菌生存能力的一种蛋白，它是一种“定居因子”，通过与浮游动物和上皮细胞表面上的糖结合来调控该细菌向两种载体上的附着。考虑到这种蛋白所扮演角色的广泛性，它可能是疫苗设计的一个有希望的目标。
“惠更斯”探测器探测“土卫六”专栏
今年1月14日，“惠更斯”探测器在“土卫六”上着陆，本期Nature上发表的7篇论文记录了这一事件。它们描述了一个与原始地球很像的世界，有天气系统和地质活动。“土卫六上的惠更斯”专栏由一篇介绍降落和着陆过程的文章（p. 758）和一篇“新闻与观点”文章开始（p. 756）。Tomasko等人（p. 765）描述了“惠更斯”降落过程中所看到的干河床和排水渠，这是证明液态甲烷以雨的形式降落在“土卫六”表面上或从冷火山喷发出来、周期性地冲刷该天体表面的证据。这篇论文将封面上的照片用到了“惠更斯”栏目中。Niemann等人（p. 779）测定了氩、氮和碳的同位素在该天体大气中的丰度，得出结论认为，没有证据表明“土卫六”上的甲烷来自生物活动。Fulchignoni等人（p. 785）获得了从该天体的上层大气直到地表的温度和压力的精确测量结果。在降落过程中，“惠更斯”记录到了闪电的证据。Zarnecki等人（p. 792）报告，该探测器降落在一个由冰粒构成的比较平的表面上，质地跟湿粘土或沙子差不多。Isra?l等人（p. 796）报告，“土卫六”云层中的气溶胶具有来自含有碳和氮的复杂有机分子的固体核。Bird等人（p. 800）发现，平均来说，“土卫六”上的风随着该星球的转动向同一方向刮，在接近地表的地方这些风非常弱，风速跟步行速度差不多。
肿瘤细胞的转移机制
很多肿瘤有向特定器官转移的倾向。对将肿瘤细胞引向特定组织的机制，我们基本上不了解，但目前的观点是，它可能涉及肿瘤细胞本身所固有的分子差异，由免疫细胞和其他组织来调控。新的研究工作表明，还存在另一个可能性：骨髓中表达VEGFR1的造血前体细胞似乎会在肿瘤细胞到达特定地点前先为它们瞄准这些目标，通过形成特定的、让它们能够生存和繁殖的环境来为转移中的漫无目标的肿瘤细胞铺平道路。转移前生境（在其中，非癌细胞可促进未来的转移）的概念是一个新概念，它提出了这样一个可能性：以VEGFR1和相关分子为目标，有可能具有治疗价值。
单个光子在原子量子记忆装置中的存取
两个小组在本期Nature上报告了在向量子计算前进的漫漫长路上所迈出的重要一步：单个光子在原子量子记忆装置中的存取。Chanelière等人从一个实验室中的一个原子量子记忆装置上生成了单个的光子，通过一个100米长的光纤对其进行传输，并将它们在第二个记忆装置中存储了一段时间。然后，原子激发又被转变成一个单个光子。以前，弱相干激光脉冲曾被在原子介质中停止和重新拾取，但单个光子却适合实现量子位。Eisaman等人报告了一个类似的方法，他们所采用的是相干控制方法，被称为“电磁诱导透明法”，用来生成、传输和存储单个光子。（Letters p. 833, 837; News and Views）第三篇论文报告了对量子通信和计算来说非常重要的另一项技术上所取得的进展：即纠缠量子位的存储和分布。Chou等人在两个相距2.8米的原子样品之间实现了纠缠，这两个样品一起存储一个量子位的信息。
降雨量对稀树草原生态系统的影响
生态学家早就在争论树木和草本在稀树草原生态系统中能够共生的机制了。根据来自非洲854个地点的数据，Sankaran等人发现，在年降雨量少于650毫米的稀树草原和年降雨量高于这个水平的稀树草原之间有一个明显的区别。在年降雨量650毫米的这个界线之下，水是林木群落结构的关键决定因素。这些稀树草原是稳定的，这里的扰动（如火灾和草食性动物的掠食）和土壤性质会改变林木覆盖，但对树木和草本的共生并不是必需的。在650毫米这个界线之上，扰动对于一个稀树草原体系的维持来势就是非常重要的了。
对多巴胺与快感之间联系的新认识
人们之所以使用会产生依赖性的药物，至少在最初是由于它们能让人产生快感；以后，长期使用会导致上瘾。有大量文献支持这样的观点：多巴胺的释放是吗啡让人产生快感的原因。一个普遍的假设是，多数会产生依赖性的药物释放多巴胺，同包括食物和性在内的其他刺激一样。多巴胺甚至被称为“快乐传输因子”。所以，当发现不能产生多巴胺的小鼠与能产生多巴胺的小鼠能有基本相同的快感反应的时候，人们不免会感到吃惊。在这个结果（是根据一种被称为“条件地点偏爱”的行为获得的，该行为被作为鼠科动物“快感”的一种度量）之前，也曾有人发现，按对糖的偏爱程度来度量，缺少多巴胺的小鼠有一个完好的奖赏系统。多巴胺与快感之间的联系也许并不像人们曾经所以为的那样。
防止蛋白聚集的机制
蛋白倾向于聚集在一起的问题是一个任何生命体系都必须克服的问题。对阿尔茨海默氏症和发病较晚的糖尿病等疾病所做的研究表明，如果蛋白的聚集不控制的话会发生什么。抑制蛋白聚集的两个体系的物质（即分子伴护者和质量控制蛋白）已经受到广泛的研究，但关于氨基酸序列所承受的选择性压力对此会有什么作用我们仍然知之甚少。现在，对巨型分子Titin所做的一项研究表明，多域蛋白的序列在演化过程中可能形成了减少误折叠和聚集的概率的本领。Titin非常适合此项研究，因为其成分“免疫球蛋白”域会展开，再重新折叠，该现象是肌肉活动的一个内在部分。研究结果表明，虽然来自不同生物的同样的“免疫球蛋白”域经常有约95%的序列身份，但在一个给定蛋白中的相邻域之间，序列身份只有约25%。计算表明，相邻域序列身份高于30-40%，可能会引起误折叠和不想要的域之间的聚集。
今天的鹿与灭绝的鹿有什么关系？
今天的鹿种与绝灭的巨型鹿或爱尔兰麋鹿之间的关系（一个争论多年的话题）已被弄清，研究人员所采用的是线粒体DNA测序方法。DNA和形态数据是从一个化石记录中获得的，这个化石记录从距今40万年前一直延伸到距今大约8000年前灭绝，跨越欧洲，从爱尔兰延伸到西伯利亚。所获得的结果支持一个早期的观点（该观点是以一般的鹿角形状为依据的，依据不是很充分），即地球上曾经有过的最大的鹿与今天的体格小得多的鹿的关系要比与麋鹿（Wapiti）和红鹿的关系更近。
Editorials
Unapproved tests on a chip p711
Prenatal genetic tests can now check for abnormalities in developing fetuses, but there is still no regulatory framework for them in the United States.
doi:10.1038/438711a
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Launching a business p711
There's little evidence that commercial approaches can radically reduce the cost of getting into space.
doi:10.1038/438711b
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Enough, already p712
No convincing case has been made for increasing the amount of plutonium held at a Californian lab.
doi:10.1038/438712a
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Top of pageResearch Highlights
Research highlights p714
doi:10.1038/438714a
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Top of pageNews
UK animal labs still under siege p716
Activists maintain pressure as building of Oxford lab resumes.
Tom Simonite and Jim Giles
doi:10.1038/438716a
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Animal-rights militancy exported to US and Europe p717
Rise in extremist activity abroad 'aided by British expertise'.
Emma Marris and Tom Simonite
doi:10.1038/438717a
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TV show gives research lobbyist a rat's-eye view of laboratory life p717
Pro-animal researcher runs the gauntlet of tests.
doi:10.1038/438717b
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Sidelines p718
doi:10.1038/438718a
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TV tests call into question cloner's stem-cell success p718
Korean star faces challenges over data.
David Cyranoski
doi:10.1038/438718b
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Avian flu centre put under threat of closure p719
Indonesian authorities halt research at frontline station.
Declan Butler
doi:10.1038/438719a
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Climate talks edge towards twin-track future p721
UN convention could complement Kyoto Protocol.
Amanda Haag
doi:10.1038/438721a
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Prospect of stricter timekeeping alarms US biologists p721
Hackles are raised over revamped guidelines.
Emma Marris
doi:10.1038/438721b
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German hostage was saving Iraq digs p722
Kidnapped archaeologist fought against looting.
Andreas von Bubnoff
doi:10.1038/438722a
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Cowrie study strikes a blow for traditional taxonomy p722
DNA barcoding fails identification test.
Erika Check
doi:10.1038/438722b
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Chairman explains Europe's research council p723
doi:10.1038/438723a
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News in brief p724
doi:10.1038/438724a
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Top of pageNews Features
Nonsense mutations: Running the red light p726
A trial drug encourages cells to ignore the signs that stop them making faulty proteins. Sound dangerous? Claire Ainsworth discovers that it could be a cure for genetic disease.
doi:10.1038/438726a
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Neutron science: Back on track? p730
Next June, a $1.4-billion neutron-scattering facility will come online in the United States. Karen Fox finds out whether this machine really can breathe fresh life into the ageing Tennessee lab that is its home.
doi:10.1038/438730a
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Fetal genetic testing: Screen test p733
A new technique could allow doctors to spot hundreds of potential genetic problems in unborn babies. But is it too soon to put it to use? Erika Check finds out.
doi:10.1038/438733a
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Top of pageBusiness
Internet star shoots for a rocket revolution p736
A newcomer to the space arena claims that his start-up launch company can buck the trend of commercial failures. Tony Reichhardt reports.
Tony Reichhardt
doi:10.1038/438736a
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In brief p737
doi:10.1038/438737a
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Market Watch p737
doi:10.1038/438737b
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Top of pageCorrespondence
Supplementary data need to be kept in public repositories p738
Carlos Santos, Judith Blake and David J. States
doi:10.1038/438738a
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Turkish science needs more than membership of the EU p738
Mehmet Somel
doi:10.1038/438738b
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Flu virus will not be sent in the regular US mail p738
Julie Louise Gerberding
doi:10.1038/438738c
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Top of pageBooks and Arts
Physics ain't what it used to be p739
Science is venturing into areas where experimental verification simply isn't possible.
George Ellis reviews The Cosmic Landscape: String Theory and the Illusion of Intelligent Design
doi:10.1038/438739a
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Pet project p740
Stephen J. O'Brien reviews The Dog and Its Genome
doi:10.1038/438740a
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On top of the world p741
doi:10.1038/438741a
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Exhibition: A close look at Darwin p741
Alan Packer reviews Darwin
doi:10.1038/438741b
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Top of pageEssay
Concept
The message of the quantum p743
Einstein challenged physics to describe "the real factual situation". But an understanding of the very concepts that he criticized a century ago may provide the best clues yet about reality 'out there'.
Anton Zeilinger
doi:10.1038/438743a
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Top of pageNews and Views
Genomics: The dog has its day p745
Domestication and selective breeding have transformed wolves into the diversity of dogs we see today. The sequence of the genome of one breed adds to our understanding of mammalian biology and genome evolution.
Hans Ellegren
doi:10.1038/438745a
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Water: Ins and outs of ice nucleation p746
Laboratory experiments point to a mechanism by which ice forms from supercooled water with surprising alacrity. Such a mechanism may help to explain ice formation in the atmosphere under certain conditions.
Srikanth Sastry
doi:10.1038/438746a
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Cell biology: Relays at the membrane p747
The Wnt signalling pathway is a major route by which the cell conveys information from its exterior to the nucleus. A gap in the sequence of signalling proteins has now been filled.
Roel Nusse
doi:10.1038/438747a
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Quantum information: Remember that photon p749
Storing single photons in atomic memories, and releasing them at a later time, is a required step on the way to quantum repeaters and long-distance quantum cryptography networks. This step has now been taken.
Philippe Grangier
doi:10.1038/438749a
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50 & 100 years ago p750
doi:10.1038/438750a
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Cancer biology: Emissaries set up new sites p750
The capacity of tumours to spread to other organs is one of their most dangerous attributes. A study of how cancer cells settle in new places shows that they send out envoys to prepare the ground for them.
Patricia S. Steeg
doi:10.1038/438750b
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Obituary: Alastair Cameron (1925–2005) p752
Astrophysicist and planetary scientist.
John Wood
doi:10.1038/438752a
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Top of pageBrief Communications
Biomechanics: No force limit on greyhound sprint speed p753
Unlike human athletes, these dogs do not need to slow down when racing round a tight bend.
James R. Usherwood and Alan M. Wilson
doi:10.1038/438753a
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Astrophysics: Is a doomsday catastrophe likely? p754
Max Tegmark and Nick Bostrom
doi:10.1038/438754a
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Corrigendum p754
doi:10.1038/438754b
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Top of pageBrief Communications Arising
Planetary science: Are there active glaciers on Mars? pE9
Alan R. Gillespie, David R. Montgomery and Amit Mushkin
doi:10.1038/nature04357
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Planetary science: Are there active glaciers on Mars? (Reply) pE10
J. W. Head, G. Neukum, R. Jaumann, H. Hiesinger, E. Hauber, M. Carr, P. Masson, B. Foing, H. Hoffmann, M. Kreslavsky, S. Werner, S. Milkovich, S. van Gasselt and The HRSC Co-Investigator Team
doi:10.1038/nature04358
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Top of pageHuygens News & Views
Planetary science: Huygens rediscovers Titan p756
The first analyses of data sent by the Huygens probe from Saturn's largest moon Titan are flooding in. They paint a picture of a 'Peter Pan' world — potentially like Earth, but with its development frozen at an early stage.
Tobias Owen
doi:10.1038/438756a
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Top of pageHuygens Articles
An overview of the descent and landing of the Huygens probe on Titan p758
Jean-Pierre Lebreton, Olivier Witasse, Claudio Sollazzo, Thierry Blancquaert, Patrice Couzin, Anne-Marie Schipper, Jeremy B. Jones, Dennis L. Matson, Leonid I. Gurvits, David H. Atkinson, Bobby Kazeminejad and Miguel Pérez-Ayúcar
doi:10.1038/nature04347
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Rain, winds and haze during the Huygens probe's descent to Titan's surface p765
M. G. Tomasko, B. Archinal, T. Becker, B. Bézard, M. Bushroe, M. Combes, D. Cook, A. Coustenis, C. de Bergh, L. E. Dafoe, L. Doose, S. Douté, A. Eibl, S. Engel, F. Gliem, B. Grieger, K. Holso, E. Howington-Kraus, E. Karkoschka, H. U. Keller, R. Kirk, R. Kramm, M. Küppers, P. Lanagan, E. Lellouch, M. Lemmon, J. Lunine, E. McFarlane, J. Moores, G. M. Prout, B. Rizk, M. Rosiek, P. Rueffer, S. E. Schröder, B. Schmitt, C. See, P. Smith, L. Soderblom, N. Thomas and R. West
doi:10.1038/nature04126
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The abundances of constituents of Titan's atmosphere from the GCMS instrument on the Huygens probe p779
H. B. Niemann, S. K. Atreya, S. J. Bauer, G. R. Carignan, J. E. Demick, R. L. Frost, D. Gautier, J. A. Haberman, D. N. Harpold, D. M. Hunten, G. Israel, J. I. Lunine, W. T. Kasprzak, T. C. Owen, M. Paulkovich, F. Raulin, E. Raaen and S. H. Way
doi:10.1038/nature04122
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In situ measurements of the physical characteristics of Titan's environment p785
M. Fulchignoni, F. Ferri, F. Angrilli, A. J. Ball, A. Bar-Nun, M. A. Barucci, C. Bettanini, G. Bianchini, W. Borucki, G. Colombatti, M. Coradini, A. Coustenis, S. Debei, P. Falkner, G. Fanti, E. Flamini, V. Gaborit, R. Grard, M. Hamelin, A. M. Harri, B. Hathi, I. Jernej, M. R. Leese, A. Lehto, P. F. Lion Stoppato, J. J. López-Moreno, T. Mäkinen, J. A. M. McDonnell, C. P. McKay, G. Molina-Cuberos, F. M. Neubauer, V. Pirronello, R. Rodrigo, B. Saggin, K. Schwingenschuh, A. Seiff, F. Simões, H. Svedhem, T. Tokano, M. C. Towner, R. Trautner, P. Withers and J. C. Zarnecki
doi:10.1038/nature04314
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A soft solid surface on Titan as revealed by the Huygens Surface Science Package p792
John C. Zarnecki, Mark R. Leese, Brijen Hathi, Andrew J. Ball, Axel Hagermann, Martin C. Towner, Ralph D. Lorenz, J. Anthony M. McDonnell, Simon F. Green, Manish R. Patel, Timothy J. Ringrose, Philip D. Rosenberg, Karl R. Atkinson, Mark D. Paton, Marek Banaszkiewicz, Benton C. Clark, Francesca Ferri, Marcello Fulchignoni, Nadeem A. L. Ghafoor, Günter Kargl, Håkan Svedhem, John Delderfield, Manuel Grande, David J. Parker, Peter G. Challenor and John E. Geake
doi:10.1038/nature04211
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Top of pageHuygens Letters
Complex organic matter in Titan's atmospheric aerosols from in situ pyrolysis and analysis p796
G. Israël, C. Szopa, F. Raulin, M. Cabane, H. B. Niemann, S. K. Atreya, S. J. Bauer, J.-F. Brun, E. Chassefière, P. Coll, E. Condé, D. Coscia, A. Hauchecorne, P. Millian, M.-J. Nguyen, T. Owen, W. Riedler, R. E. Samuelson, J.-M. Siguier, M. Steller, R. Sternberg and C. Vidal-Madjar
doi:10.1038/nature04349
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The vertical profile of winds on Titan p800
M. K. Bird, M. Allison, S. W. Asmar, D. H. Atkinson, I. M. Avruch, R. Dutta-Roy, Y. Dzierma, P. Edenhofer, W. M. Folkner, L. I. Gurvits, D. V. Johnston, D. Plettemeier, S. V. Pogrebenko, R. A. Preston and G. L. Tyler
doi:10.1038/nature04060
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Top of pageArticles
Genome sequence, comparative analysis and haplotype structure of the domestic dog p803
Kerstin Lindblad-Toh, Claire M Wade, Tarjei S. Mikkelsen, Elinor K. Karlsson, David B. Jaffe, Michael Kamal, Michele Clamp, Jean L. Chang, Edward J. Kulbokas, III, Michael C. Zody, Evan Mauceli, Xiaohui Xie, Matthew Breen, Robert K. Wayne, Elaine A. Ostrander, Chris P. Ponting, Francis Galibert, Douglas R. Smith, Pieter J. deJong, Ewen Kirkness, Pablo Alvarez, Tara Biagi, William Brockman, Jonathan Butler, Chee-Wye Chin, April Cook, James Cuff, Mark J. Daly, David DeCaprio, Sante Gnerre, Manfred Grabherr, Manolis Kellis, Michael Kleber, Carolyne Bardeleben, Leo Goodstadt, Andreas Heger, Christophe Hitte, Lisa Kim, Klaus-Peter Koepfli, Heidi G. Parker, John P. Pollinger, Stephen M. J. Searle, Nathan B. Sutter, Rachael Thomas and Caleb Webber, Broad Sequencing Platform members and Eric S. Lander
doi:10.1038/nature04338
Abstract | Full Text | PDF (1,210K) | Supplementary information
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VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche p820
Rosandra N. Kaplan, Rebecca D. Riba, Stergios Zacharoulis, Anna H. Bramley, Loïc Vincent, Carla Costa, Daniel D. MacDonald, David K. Jin, Koji Shido, Scott A. Kerns, Zhenping Zhu, Daniel Hicklin, Yan Wu, Jeffrey L. Port, Nasser Altorki, Elisa R. Port, Davide Ruggero, Sergey V. Shmelkov, Kristian K. Jensen, Shahin Rafii and David Lyden
doi:10.1038/nature04186
Abstract | Full Text | PDF (907K) | Supplementary information
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Top of pageLetters
Measurement-induced entanglement for excitation stored in remote atomic ensembles p828
C. W. Chou, H. de Riedmatten, D. Felinto, S. V. Polyakov, S. J. van Enk and H. J. Kimble
doi:10.1038/nature04353
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Storage and retrieval of single photons transmitted between remote quantum memories p833
T. Chanelière, D. N. Matsukevich, S. D. Jenkins, S.-Y. Lan, T. A. B. Kennedy and A. Kuzmich
doi:10.1038/nature04315
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Electromagnetically induced transparency with tunable single-photon pulses p837
M. D. Eisaman, A. André, F. Massou, M. Fleischhauer, A. S. Zibrov and M. D. Lukin
doi:10.1038/nature04327
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A lithospheric instability origin for Columbia River flood basalts and Wallowa Mountains uplift in northeast Oregon p842
T. C. Hales, D. L. Abt, E. D. Humphreys and J. J. Roering
doi:10.1038/nature04313
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Determinants of woody cover in African savannas p846
Mahesh Sankaran, Niall P. Hanan, Robert J. Scholes, Jayashree Ratnam, David J. Augustine, Brian S. Cade, Jacques Gignoux, Steven I. Higgins, Xavier Le Roux, Fulco Ludwig, Jonas Ardo, Feetham Banyikwa, Andries Bronn, Gabriela Bucini, Kelly K. Caylor, Michael B. Coughenour, Alioune Diouf, Wellington Ekaya, Christie J. Feral, Edmund C. February, Peter G. H. Frost, Pierre Hiernaux, Halszka Hrabar, Kristine L. Metzger, Herbert H. T. Prins, Susan Ringrose, William Sea, Jörg Tews, Jeff Worden and Nick Zambatis
doi:10.1038/nature04070
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The phylogenetic position of the 'giant deer' Megaloceros giganteus p850
A. M. Lister, C. J. Edwards, D. A. W. Nock, M. Bunce, I. A. van Pijlen, D. G. Bradley, M. G. Thomas and I. Barnes
doi:10.1038/nature04134
First paragraph | Full Text | PDF (229K) | Supplementary information
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Morphine reward in dopamine-deficient mice p854
Thomas S. Hnasko, Bethany N. Sotak and Richard D. Palmiter
doi:10.1038/nature04172
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BMP inhibition-driven regulation of six-3 underlies induction of newt lens regeneration p858
Matthew W. Grogg, Mindy K. Call, Mitsumasa Okamoto, M. Natalia Vergara, Katia Del Rio-Tsonis and Panagiotis A. Tsonis
doi:10.1038/nature04175
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A colonization factor links Vibrio cholerae environmental survival and human infection p863
Thomas J. Kirn, Brooke A. Jude and Ronald K. Taylor
doi:10.1038/nature04249
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Casein kinase 1 couples Wnt receptor activation to cytoplasmic signal transduction p867
Gary Davidson, Wei Wu, Jinlong Shen, Josipa Bilic, Ursula Fenger, Peter Stannek, Andrei Glinka and Christof Niehrs
doi:10.1038/nature04170
First paragraph | Full Text | PDF (487K) | Supplementary information
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A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation p873
Xin Zeng, Keiko Tamai, Brad Doble, Shitao Li, He Huang, Raymond Habas, Heidi Okamura, Jim Woodgett and Xi He
doi:10.1038/nature04185
First paragraph | Full Text | PDF (513K) | Supplementary information
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The importance of sequence diversity in the aggregation and evolution of proteins p878
Caroline F. Wright, Sarah A. Teichmann, Jane Clarke and Christopher M. Dobson
doi:10.1038/nature04195
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Top of pageNaturejobs
Prospect
Seeking soft skills p883
Career panel points to off-the-bench skills.
Paul Smaglik
doi:10.1038/nj7069-883a
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Postdocs and Students
Toddlers, teens and test tubes p884
Young careers and young families can leave investigators feeling stretched. Kendall Powell finds out how to keep the two from clashing.
Kendall Powell
doi:10.1038/nj7069-884a
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Top of pageFutures
Transport of delight p888
The highs and lows of commuting.
Roland Denison
doi:10.1038/438888a
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